Metabolic Weekly
Nutrition

GLP-1 Users: Don't Miss These Critical Micronutrient Insights

While GLP-1 receptor agonists offer significant benefits for weight management and metabolic health, new research highlights a critical, often overlooked side effect: micronutrient deficiencies. A recent meta-analysis of over 12,000 patients revealed that nearly a quarter of individuals starting GLP-1 therapy developed at least one diagnosed deficiency. This raises important questions about long-term health and the need for proactive nutritional strategies to ensure patients receive the vital nutrients their bodies need to thrive. Discover what essential vitamins and minerals might be at risk and how to safeguard your health while on these transformative medications.

Renata Solís

Renata Solís

Senior Health Writer

Dr. Marcus Trent

Medically Reviewed by

Dr. Marcus Trent

Obesity Medicine Specialist

Published March 14, 2026 · 7 min read

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In a comprehensive meta-analysis evaluating over 12,000 patients, 24.2% of individuals initiating GLP-1 receptor agonist therapy developed at least one diagnosed micronutrient deficiency within 12 months, with vitamin D deficiency being the most prevalent, impacting 17.8% of users, according to data published in the Journal of Clinical Endocrinology & Metabolism in 2023.

Last Updated: May 2024

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Renata Solís

Renata Solís

Senior Health Writer

Health journalist covering GLP-1 medications, metabolic health, and the telehealth industry. All articles are fact-checked and medically reviewed.

Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Consult with a qualified healthcare provider before starting any medication. Last updated: March 14, 2026.